GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10935120 | 1 | rs1534026 | chr3:134284767 | CEP63 | chr3:134204575-134293852:+ | 0.23 | 3.97 | 8.43E-5 | Height |
| BLCA | cis | rs9309473 | 1 | rs1534471 | chr2:73647508 | ALMS1P | chr2:73872046-73912692:+ | 0.37 | 5.47 | 8.03E-8 | Metabolite levels |
| BLCA | cis | rs7611238 | 1 | rs1538767 | chr3:195007852 | C3orf21 | chr3:194789015-194991895:- | 0.3 | 5.91 | 7.67E-9 | Body mass index |
| BLCA | cis | rs11976180 | 1 | rs1540894 | chr7:143767676 | ARHGEF35 | chr7:143883677-143892736:- | -0.31 | -5.44 | 9.44E-8 | Obesity-related traits |
| BLCA | cis | rs2243480 | 1 | rs1546059 | chr7:65654709 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.75 | 2.86E-6 | Diabetic kidney disease |
| BLCA | cis | rs6805251 | 1 | rs1546753 | chr3:119557075 | KTELC1 | chr3:119187785-119213552:+ | 0.23 | 3.98 | 8.29E-5 | HDL cholesterol |
| BLCA | cis | rs2243480 | 1 | rs1553174 | chr7:65731194 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.72 | 3.27E-6 | Diabetic kidney disease |
| BLCA | cis | rs10461617 | 1 | rs1559282 | chr5:56099375 | C5orf35 | chr5:56205103-56213010:+ | 0.65 | 9.62 | 8.98E-20 | Type 2 diabetes |
| BLCA | cis | rs199347 | 1 | rs156425 | chr7:23309119 | GPNMB | chr7:23286316-23314728:+ | 0.24 | 4.07 | 5.6E-5 | Parkinson's disease |
| BLCA | cis | rs8030379 | 1 | rs1564472 | chr15:84569793 | C15orf40 | chr15:83657724-83680393:- | 0.24 | 4.1 | 5.01E-5 | Waist circumference adjusted for body mass index;Waist circumference |
| BLCA | cis | rs9815354 | 1 | rs1564716 | chr3:41862613 | ULK4 | chr3:41288091-42003660:- | 0.62 | 9.63 | 8.26E-20 | Diastolic blood pressure |
| BLCA | cis | rs15676 | 1 | rs15676 | chr9:131572027 | ENDOG | chr9:131580779-131584954:+ | -0.18 | -4 | 7.75E-5 | Blood metabolite levels |
| BLCA | cis | rs1577917 | 1 | rs1577917 | chr6:86691940 | SNHG5 | chr6:86386726-86388451:- | -0.54 | -9.69 | 5.26E-20 | Response to antipsychotic treatment |
| BLCA | cis | rs1577917 | 1 | rs1577919 | chr6:86757296 | SNHG5 | chr6:86386726-86388451:- | -0.53 | -9.25 | 1.64E-18 | Response to antipsychotic treatment |
| BLCA | cis | rs9475752 | 1 | rs1599280 | chr6:56792576 | BEND6 | chr6:56819773-56892138:+ | -0.29 | -3.97 | 8.44E-5 | Menarche (age at onset) |